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Pulmonary Cell NewsEpicardial-derived cardiac fibroblasts and epithelial cells express paracrine factors, including TGFβ1 and FGFs, which mediate EMT, and contribute to the pathogenesis of myocardial fibrosis, apoptosis, arrhythmias, and cardiac dysfunction in a mouse model of arrhythmogenic cardiomyopathy.
[Circulation]
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Yuan Ping, Cheedipudi Sirisha M., Rouhi Leila, Fan Siyang, Simon Lukas, Zhao Zhongming, Hong Kui, Gurha Priyatansh, & Marian Ali J. (n.d.). Single Cell RNA-Sequencing Uncovers Paracrine Functions of the Epicardial-Derived Cells in Arrhythmogenic Cardiomyopathy. Circulation, 0(0). https://doi.org/10.1161/CIRCULATIONAHA.120.052928 Cite
