Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell NewsResearchers showed that extracellular vesicles isolated from mouse and human intestinal organoids modulated inflammatory responses of various immune cells including mouse bone-marrow derived-macrophages, dendritic cells, microglia cells, and human monocytes.
[Mucosal Immunology]
6445218 4C6T2KMB items 1 apa 0 default asc 1 161260 https://www.stemcellsciencenews.com/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3A%22zotpress-b308a6452c42fe607512f1a9984419e3%22%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%224C6T2KMB%22%2C%22library%22%3A%7B%22id%22%3A6445218%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Zhang%20et%20al.%22%2C%22parsedDate%22%3A%222021-04-14%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EZhang%2C%20Y.%2C%20Yan%2C%20Y.%2C%20Meng%2C%20J.%2C%20Girotra%2C%20M.%2C%20Ramakrishnan%2C%20S.%2C%20%26amp%3B%20Roy%2C%20S.%20%282021%29.%20Immune%20modulation%20mediated%20by%20extracellular%20vesicles%20of%20intestinal%20organoids%20is%20disrupted%20by%20opioids.%20%3Ci%3EMucosal%20Immunology%3C%5C%2Fi%3E%2C%201%26%23x2013%3B12.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41385-021-00392-9%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41385-021-00392-9%3C%5C%2Fa%3E%20%3Ca%20title%3D%27Cite%20in%20RIS%20Format%27%20class%3D%27zp-CiteRIS%27%20href%3D%27https%3A%5C%2F%5C%2Fwww.stemcellsciencenews.com%5C%2Fwp-content%5C%2Fplugins%5C%2Fzotpress%5C%2Flib%5C%2Frequest%5C%2Frequest.cite.php%3Fapi_user_id%3D6445218%26amp%3Bitem_key%3D4C6T2KMB%27%3ECite%3C%5C%2Fa%3E%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Immune%20modulation%20mediated%20by%20extracellular%20vesicles%20of%20intestinal%20organoids%20is%20disrupted%20by%20opioids%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yue%22%2C%22lastName%22%3A%22Zhang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yan%22%2C%22lastName%22%3A%22Yan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jingjing%22%2C%22lastName%22%3A%22Meng%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mohit%22%2C%22lastName%22%3A%22Girotra%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sundaram%22%2C%22lastName%22%3A%22Ramakrishnan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sabita%22%2C%22lastName%22%3A%22Roy%22%7D%5D%2C%22abstractNote%22%3A%22Extracellular%20vesicles%20%28EVs%29%20are%20effective%20mediators%20of%20intercellular%20communications%20between%20enterocytes%20and%20immune%20cells.%20The%20current%20study%20showed%20that%20EVs%20isolated%20from%20mouse%20and%20human%20intestinal%20organoids%20modulated%20inflammatory%20responses%20of%20various%20immune%20cells%20including%20mouse%20bone-marrow%20derived-macrophages%2C%20dendritic%20cells%2C%20microglia%20cells%2C%20and%20human%20monocytes.%20EVs%20suppressed%20LPS-elicited%20cytokine%20production%20in%20these%20cells%20while%20morphine%20abolished%20EVs%5Cu2019%20immune%20modulatory%20effects.%20Microarray%20analysis%20showed%20that%20various%20microRNAs%2C%20especially%20Let-7%2C%20contributed%20to%20EV-mediated%20immune%20modulation.%20Using%20murine%20models%2C%20we%20showed%20that%20injection%20of%20EVs%20derived%20from%20intestinal%20organoids%20reduced%20endotoxin-induced%20systemic%20inflammation%20and%20alleviated%20the%20symptoms%20of%20DSS-induced%20colitis.%20EVs%20derived%20from%20morphine-treated%20organoids%20failed%20to%20suppress%20the%20immune%20response%20in%20both%20these%20models.%20Our%20study%20suggests%20that%20EVs%20derived%20from%20intestinal%20crypt%20cells%20play%20crucial%20roles%20in%20maintaining%20host%20homeostasis%20and%20opioid%20use%20is%20a%20risk%20factor%20for%20exacerbating%20inflammation%20in%20patients%20with%20inflammatory%20diseases%20such%20as%20sepsis%20and%20colitis.%22%2C%22date%22%3A%222021-04-14%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1038%5C%2Fs41385-021-00392-9%22%2C%22ISSN%22%3A%221935-3456%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.nature.com%5C%2Farticles%5C%2Fs41385-021-00392-9%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222021-04-15T22%3A15%3A48Z%22%7D%7D%5D%7D
Zhang, Y., Yan, Y., Meng, J., Girotra, M., Ramakrishnan, S., & Roy, S. (2021). Immune modulation mediated by extracellular vesicles of intestinal organoids is disrupted by opioids. Mucosal Immunology, 1–12. https://doi.org/10.1038/s41385-021-00392-9 Cite
