Integrin β7 Inhibits Colorectal Cancer Pathogenesis via Maintaining Anti-Tumor Immunity

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Researchers found that the number of β7+ cells decreased significantly in tumor tissue compared with adjacent normal tissue. β7 expression decreased in tumor-derived compared to normal tissue-derived CD8+ T cells.
[Cancer Immunology Research]
Zhang, Y., Xie, R., Zhang, H., Zheng, Y., Lin, C., Yang, L., Huang, M., Li, M., Song, F., Lu, L., Yang, M., Liu, Y., Wei, Q., Li, J., & Chen, J. (2021). Integrin β7 inhibits colorectal cancer pathogenesis via maintaining anti-tumor immunity. Cancer Immunology Research. https://doi.org/10.1158/2326-6066.CIR-20-0879 Cite
Abstract