Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell NewsScientists studied the importance of paracrine signaling in the glioma microenvironment by focusing on the celecoxib-mediated role of chemokines C–C motif ligand 2, C-X-C ligand 10, and their receptors, CCR2 and CXCR3, in glioma stem cells (GSCs) and a GSC-bearing malignant glioma model.
[Scientific Reports]
6807162 6Z5A9PN9 items 1 apa 0 default asc 1 154250 https://www.stemcellsciencenews.com/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3A%22zotpress-b7520daefeef8b2dd83bcc4e4762c501%22%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%226Z5A9PN9%22%2C%22library%22%3A%7B%22id%22%3A6807162%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Shono%20et%20al.%22%2C%22parsedDate%22%3A%222020-09-17%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EShono%2C%20K.%2C%20Yamaguchi%2C%20I.%2C%20Mizobuchi%2C%20Y.%2C%20Kagusa%2C%20H.%2C%20Sumi%2C%20A.%2C%20Fujihara%2C%20T.%2C%20Nakajima%2C%20K.%2C%20Kitazato%2C%20K.%20T.%2C%20Matsuzaki%2C%20K.%2C%20Saya%2C%20H.%2C%20%26amp%3B%20Takagi%2C%20Y.%20%282020%29.%20Downregulation%20of%20the%20CCL2%5C%2FCCR2%20and%20CXCL10%5C%2FCXCR3%20axes%20contributes%20to%20antitumor%20effects%20in%20a%20mouse%20model%20of%20malignant%20glioma.%20%3Ci%3EScientific%20Reports%3C%5C%2Fi%3E%2C%20%3Ci%3E10%3C%5C%2Fi%3E%281%29%2C%2015286.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41598-020-71857-3%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41598-020-71857-3%3C%5C%2Fa%3E%20%3Ca%20title%3D%27Cite%20in%20RIS%20Format%27%20class%3D%27zp-CiteRIS%27%20href%3D%27https%3A%5C%2F%5C%2Fwww.stemcellsciencenews.com%5C%2Fwp-content%5C%2Fplugins%5C%2Fzotpress%5C%2Flib%5C%2Frequest%5C%2Frequest.cite.php%3Fapi_user_id%3D6807162%26amp%3Bitem_key%3D6Z5A9PN9%27%3ECite%3C%5C%2Fa%3E%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Downregulation%20of%20the%20CCL2%5C%2FCCR2%20and%20CXCL10%5C%2FCXCR3%20axes%20contributes%20to%20antitumor%20effects%20in%20a%20mouse%20model%20of%20malignant%20glioma%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kenji%22%2C%22lastName%22%3A%22Shono%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Izumi%22%2C%22lastName%22%3A%22Yamaguchi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yoshifumi%22%2C%22lastName%22%3A%22Mizobuchi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hiroshi%22%2C%22lastName%22%3A%22Kagusa%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Akiko%22%2C%22lastName%22%3A%22Sumi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Toshitaka%22%2C%22lastName%22%3A%22Fujihara%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kohei%22%2C%22lastName%22%3A%22Nakajima%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Keiko%20T.%22%2C%22lastName%22%3A%22Kitazato%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kazuhito%22%2C%22lastName%22%3A%22Matsuzaki%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hideyuki%22%2C%22lastName%22%3A%22Saya%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yasushi%22%2C%22lastName%22%3A%22Takagi%22%7D%5D%2C%22abstractNote%22%3A%22Glioblastoma%20multiforme%20involves%20glioma%20stem%20cells%20%28GSCs%29%20that%20are%20resistant%20to%20various%20therapeutic%20approaches.%20Here%2C%20we%20studied%20the%20importance%20of%20paracrine%20signaling%20in%20the%20glioma%20microenvironment%20by%20focusing%20on%20the%20celecoxib-mediated%20role%20of%20chemokines%20C%5Cu2013C%20motif%20ligand%202%20%28CCL2%29%2C%20C-X-C%20ligand%2010%20%28CXCL10%29%2C%20and%20their%20receptors%2C%20CCR2%20and%20CXCR3%2C%20in%20GSCs%20and%20a%20GSC-bearing%20malignant%20glioma%20model.%20C57BL%5C%2F6%20mice%20were%20injected%20with%20orthotopic%20GSCs%20intracranially%20and%20divided%20into%20groups%20administered%20either%2010%20or%2030%5Cu00a0mg%5C%2Fkg%20celecoxib%2C%20or%20saline%20to%20examine%20the%20antitumor%20effects%20associated%20with%20chemokine%20expression.%20In%20GSCs%2C%20we%20analyzed%20cell%20viability%20and%20expression%20of%20chemokines%20and%20their%20receptors%20in%20the%20presence%5C%2Fabsence%20of%20celecoxib.%20In%20the%20malignant%20glioma%20model%2C%20celecoxib%20exhibited%20antitumor%20effects%20in%20a%20dose%20dependent%20manner%20and%20decreased%20protein%20and%20mRNA%20levels%20of%20Ccl2%20and%20CxcL10%20and%20Cxcr3%20but%20not%20of%20Ccr2.%20CCL2%20and%20CXCL10%20co-localized%20with%20Nestin%2B%20stem%20cells%2C%20CD16%2B%20or%20CD163%2B%20macrophages%20and%20Iba-1%2B%20microglia.%20In%20GSCs%2C%20celecoxib%20inhibited%20Ccl2%20and%20Cxcr3%20expression%20in%20a%20nuclear%20factor-kappa%20B-dependent%20manner%20but%20not%20Ccr2%20and%20CxcL10.%20Moreover%2C%20Ccl2%20silencing%20resulted%20in%20decreased%20GSC%20viability.%20These%20results%20suggest%20that%20celecoxib-mediated%20regulation%20of%20the%20CCL2%5C%2FCCR2%20and%20CXCL10%5C%2F%20CXCR3%20axes%20may%20partially%20contribute%20to%20glioma-specific%20antitumor%20effects.%22%2C%22date%22%3A%222020-09-17%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1038%5C%2Fs41598-020-71857-3%22%2C%22ISSN%22%3A%222045-2322%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.nature.com%5C%2Farticles%5C%2Fs41598-020-71857-3%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222020-09-17T20%3A16%3A20Z%22%7D%7D%5D%7D
Shono, K., Yamaguchi, I., Mizobuchi, Y., Kagusa, H., Sumi, A., Fujihara, T., Nakajima, K., Kitazato, K. T., Matsuzaki, K., Saya, H., & Takagi, Y. (2020). Downregulation of the CCL2/CCR2 and CXCL10/CXCR3 axes contributes to antitumor effects in a mouse model of malignant glioma. Scientific Reports, 10(1), 15286. https://doi.org/10.1038/s41598-020-71857-3 Cite
