Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell NewsScientists assessed the current literature detailing the effects of ω-3 polyunsaturated fatty acids (PUFAs) on epithelial cells. Marine-derived ω-3 PUFAs, eicosapentanoic acid and docosahexanoic acid, as well as plant-derived alpha-linolenic acid, are incorporated into intestinal epithelial cell membranes, prevent changes to epithelial permeability, inhibit the production of pro-inflammatory cytokines and eicosanoids and induce the production of anti-inflammatory eicosanoids and docosanoids.
[Foods]
1254621 {1254621:D29JSMDA} apa 50 1 158266 https://www.stemcellsciencenews.com/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3A%22zotpress-d7bc1e2c819a8b41a9869c48a901e1c2%22%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%22D29JSMDA%22%2C%22library%22%3A%7B%22id%22%3A1254621%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Durkin%20et%20al.%22%2C%22parsedDate%22%3A%222021-01%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EDurkin%2C%20L.%20A.%2C%20Childs%2C%20C.%20E.%2C%20%26amp%3B%20Calder%2C%20P.%20C.%20%282021%29.%20Omega-3%20Polyunsaturated%20Fatty%20Acids%20and%20the%20Intestinal%20Epithelium%26%23x2014%3BA%20Review.%20%3Ci%3EFoods%3C%5C%2Fi%3E%2C%20%3Ci%3E10%3C%5C%2Fi%3E%281%29%2C%20199.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.3390%5C%2Ffoods10010199%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.3390%5C%2Ffoods10010199%3C%5C%2Fa%3E%20%3Ca%20title%3D%27Cite%20in%20RIS%20Format%27%20class%3D%27zp-CiteRIS%27%20href%3D%27https%3A%5C%2F%5C%2Fwww.stemcellsciencenews.com%5C%2Fwp-content%5C%2Fplugins%5C%2Fzotpress%5C%2Flib%5C%2Frequest%5C%2Frequest.cite.php%3Fapi_user_id%3D1254621%26amp%3Bitem_key%3DD29JSMDA%27%3ECite%3C%5C%2Fa%3E%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Omega-3%20Polyunsaturated%20Fatty%20Acids%20and%20the%20Intestinal%20Epithelium%5Cu2014A%20Review%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Luke%20A.%22%2C%22lastName%22%3A%22Durkin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Caroline%20E.%22%2C%22lastName%22%3A%22Childs%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Philip%20C.%22%2C%22lastName%22%3A%22Calder%22%7D%5D%2C%22abstractNote%22%3A%22Epithelial%20cells%20%28enterocytes%29%20form%20part%20of%20the%20intestinal%20barrier%2C%20the%20largest%20human%20interface%20between%20the%20internal%20and%20external%20environments%2C%20and%20responsible%20for%20maintaining%20regulated%20intestinal%20absorption%20and%20immunological%20control.%20Under%20inflammatory%20conditions%2C%20the%20intestinal%20barrier%20and%20its%20component%20enterocytes%20become%20inflamed%2C%20leading%20to%20changes%20in%20barrier%20histology%2C%20permeability%2C%20and%20chemical%20mediator%20production.%20Omega-3%20%28%26omega%3B-3%29%20polyunsaturated%20fatty%20acids%20%28PUFAs%29%20can%20influence%20the%20inflammatory%20state%20of%20a%20range%20of%20cell%20types%2C%20including%20endothelial%20cells%2C%20monocytes%2C%20and%20macrophages.%20This%20review%20aims%20to%20assess%20the%20current%20literature%20detailing%20the%20effects%20of%20%26omega%3B-3%20PUFAs%20on%20epithelial%20cells.%20Marine-derived%20%26omega%3B-3%20PUFAs%2C%20eicosapentaenoic%20acid%20and%20docosahexaenoic%20acid%2C%20as%20well%20as%20plant-derived%20alpha-linolenic%20acid%2C%20are%20incorporated%20into%20intestinal%20epithelial%20cell%20membranes%2C%20prevent%20changes%20to%20epithelial%20permeability%2C%20inhibit%20the%20production%20of%20pro-inflammatory%20cytokines%20and%20eicosanoids%20and%20induce%20the%20production%20of%20anti-inflammatory%20eicosanoids%20and%20docosanoids.%20Altered%20inflammatory%20markers%20have%20been%20attributed%20to%20changes%20in%20activity%20and%5C%2For%20expression%20of%20proteins%20involved%20in%20inflammatory%20signalling%20including%20nuclear%20factor%20kappa-light-chain-enhancer%20of%20activated%20B%20cells%20%28NF-%26kappa%3BB%29%2C%20peroxisome%20proliferator%20activated%20receptor%20%28PPAR%29%20%26alpha%3B%20and%20%26gamma%3B%2C%20G-protein%20coupled%20receptor%20%28GPR%29%20120%20and%20cyclooxygenase%20%28COX%29-2.%20Effective%20doses%20for%20each%20%26omega%3B-3%20PUFA%20are%20difficult%20to%20determine%20due%20to%20inconsistencies%20in%20dose%20and%20time%20of%20exposure%20between%20different%20in%20vitro%20models%20and%20between%20in%20vivo%20and%20in%20vitro%20models.%20Further%20research%20is%20needed%20to%20determine%20the%20anti-inflammatory%20potential%20of%20less-studied%20%26omega%3B-3%20PUFAs%2C%20including%20docosapentaenoic%20acid%20and%20stearidonic%20acid.%22%2C%22date%22%3A%222021%5C%2F1%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.3390%5C%2Ffoods10010199%22%2C%22ISSN%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.mdpi.com%5C%2F2304-8158%5C%2F10%5C%2F1%5C%2F199%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222021-01-22T20%3A03%3A32Z%22%7D%7D%5D%7D
Durkin, L. A., Childs, C. E., & Calder, P. C. (2021). Omega-3 Polyunsaturated Fatty Acids and the Intestinal Epithelium—A Review. Foods, 10(1), 199. https://doi.org/10.3390/foods10010199 Cite
